You could easily spend a whole day exploring the area around the Vatican. Start at the Piazza di San Pietro, which Bernini designed to look like arms extended in an embrace. Besides St. Peter’s Basilica, the absolute must-see is the Vatican Museums, which contain Michelangelo’s Sistine Chapel. Other highlights in the 1,400-room palace include the Raphael Rooms, old master paintings, and antique sculptures.

Just south of Vatican City stands Castel Sant’Angelo, where popes sought solace during sieges. Climb to the top for splendid views of Vatican City and the Tiber. At its base you can see the Ponte Sant’Angelo with Bernini’s exquisitely carved marble angels.